SFB Transregio 221|Publikationen
2024
Hammon K, Renner K, Althammer M, Voll F, Babl N, Decking SM, Siska PJ, Matos C, Conejo ZEC, Mendes K, Einwag F, Siegmund H, Iberl S, Berger RS, Dettmer K, Schoenmehl R, Brochhausen C, Herr W, Oefner PJ, Rehli M, Thomas S, Kreutz M. D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells. Haematologica 2024 Jan 18; doi: 10.3324/haematol.2023.283597. Online ahead of print.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, KretschmannS, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G. CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. N Engl J Med. 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673.
Richter S, Böttcher M, Stoll A, Zeremski V, Völkl S, Mackensen A, Ekici AB, Jacobs B, Mougiakakos D. Increased PD-1 expression oncirculating T-cells correlates with inferior outcome after autologous stem cell transplantation. Transplant Cell Ther. 2024 Mar 7;S2666-6367(24)00257-4. doi: 10.1016/j.jtct.2024.03.005. Epub ahead of print. PMID: 38460727.
Bülow S, Ederer KU, Holzinger JM, Zeller L, Werner M, Toelge M, Pfab C, Hirsch S, Göpferich F, Hiergeist A, Berberich-Siebelt F, Gessner A. Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response. Cell Rep. 2024 Mar 26;43(3):113929. doi: 10.1016/j.celrep.2024.113929. Epub 2024 Mar 7.
Anany MA, Haack S, Lang I, Dahlhoff J, Vargas JG, Steinfatt T, Päckert L, Weisenberger D, Zaitseva O, Medler J, Kucka K, Zhang T, Van Belle T, van Rompaey L, Beilhack A, Wajant H. Generic design principles for antibody-based tumour necrosis factor (TNF) receptor 2 (TNFR2) agonists with FcγR-independent agonism. Theranostics 2024 Jan 1;14(2):496-509. doi: 10.7150/thno.84404. eCollection 2024.
Thiele Orberg E, Meedt E, Hiergeist A, Xue J, Heinrich P, Ru J, Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S, Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C, Gigl M, Fischer JC, Janssen KP, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A, Deng L, Holler E, Poeck H. Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nat Cancer 2024 Jan;5(1):187-208. doi: 10.1038/s43018-023-00669-x. Epub 2024 Jan 3.PMID: 3817233.
Schreiber L, Ghimire S, Hiergeist A, Renner K, Althammer M, Babl N, Peuker A, Schoenhammer G, Hippe K, Gessner A, Albrecht C, Pielmeier F, Büttner-Herold M, Bruns H, Hoffmann P, Herr W, Holler E, Peter K, Kreutz M, Matos C. Strain specific differences in vitamin D3 response: impact on gut homeostasis. Front Immunol. 2024 Mar 1;15:1347835. doi: 10.3389/fimmu.2024.1347835. eCollection 2024.PMID: 38495883.
Dittmar DJ, Pielmeier F, Strieder N, Fischer A, Herbst M, Stanewsky H, Wenzl N, Röseler E, Eder R, Gebhard C, Schwarzfischer-Pfeilschifter L, Albrecht C, Herr W, Edinger M, Hoffmann P, Rehli M. Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease Nat Commun. 2024 Apr 15;15(1):3224. doi: 10.1038/s41467-024-47575-z.PMID: 38622133.
Winkler J, Tittlbach H, Schneider A, Vasova I, Strobel J, Herold S, Maas S, Spriewald BM, Repp R, Kordelas L, Mach M, Wolff D, Edinger M, Mackensen A, Winkler TH. Adoptive transfer of donor-B lymphocytes: a phase I/IIa study for patients after allogeneic stem cell transplantation. Blood Adv. 2024 doi: 10.1182/bloodadvances.2023012305.
Rasbach L, Caliskan A, Saderi F, Dandekar T, Breitenbach T. An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts. PLoS One 2024 Apr 17;19(4):e0302045. doi: 10.1371/journal.pone.0302045. PMID: 38630692; PMCID: PMC11023401.
Salihoglu R, Balkenhol J, Dandekar G, Liang C, Dandekar T, Bencurova E. Cat-E: A comprehensive web tool for exploring cancer targeting strategies. Comput Struct Biotechnol J. 2024 Mar 27;23:1376-1386. doi:10.1016/j.csbj.2024.03.024. PMID: 38596315; PMCID: PMC11001601.
Liang C, Spoerl S, Xiao Y, Habenicht KM, Haeusl SS, Sandner I, Winkler J, Strieder N, Eder R, Stanewsky H, Alexiou CH, Dudziak D, Rosenwald A, Edinger M, Rehli M, Hoffmann P, Winkler TH, Berberich-Siebelt F. Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood. Commun Biol. 2024; doi.org/10.1038/s42003-024-06563-1.
2023
Baur, R. et al. (2023) ‘Accumulation of T-cell-suppressive PD-L1 high extracellular vesicles is associated with GvHD and might impact GvL efficacy’, Journal for ImmunoTherapy of Cancer, 11(3), p. e006362. Available at: https://doi.org/10.1136/jitc-2022-006362.
Bencurova, E. et al. (2023) ‘DNA storage—from natural biology to synthetic biology’, Computational and Structural Biotechnology Journal, 21, pp. 1227–1235. Available at: https://doi.org/10.1016/j.csbj.2023.01.045.
Bergmann, C. et al. (2023) ‘Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells’, Annals of the Rheumatic Diseases, 82(8), pp. 1117–1120. Available at: https://doi.org/10.1136/ard-2023-223952.
Bittner, S., Hehlgans, T. and Feuerer, M. (2023) ‘Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond’, Trends in Immunology, 44(6), pp. 468–483. Available at: https://doi.org/10.1016/j.it.2023.04.005.
Caliskan, A., Dangwal, S. and Dandekar, T. (2023) ‘Metadata integrity in bioinformatics: Bridging the gap between data and knowledge’, Computational and Structural Biotechnology Journal, 21, pp. 4895–4913. Available at: https://doi.org/10.1016/j.csbj.2023.10.006.
Haghikia, A. et al. (2023) ‘Anti-CD19 CAR T cells for refractory myasthenia gravis’, The Lancet Neurology, 22(12), pp. 1104–1105. Available at: https://doi.org/10.1016/S1474-4422(23)00375-7.
Heidegger, S. et al. (2023) ‘Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy’, Cell Reports Medicine, 4(9), p. 101171. Available at: https://doi.org/10.1016/j.xcrm.2023.101171.
Hippe, K. et al. (2023) ‘Round-Robin test for the histological diagnosis of acute colonic Graft-versus-Host disease validating established histological criteria and grading systems’, Virchows Archiv, 483(1), pp. 47–58. Available at: https://doi.org/10.1007/s00428-023-03544-3.
Jarosch, S. et al. (2023) ‘Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD’, Cell Reports Medicine, 4(7), p. 101125. Available at: https://doi.org/10.1016/j.xcrm.2023.101125.
Joachim, L. et al. (2023) ‘The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors’, eBioMedicine, 97, p. 104834. Available at: https://doi.org/10.1016/j.ebiom.2023.104834.
Kaltdorf, M. et al. (2023) ‘Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis’, Scientific Reports, 13(1), p. 1855. Available at: https://doi.org/10.1038/s41598-022-27098-7.
Karl, F. et al. (2023) ‘Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT’, Blood, 141(13), pp. 1626–1639. Available at: https://doi.org/10.1182/blood.2022017267.
Kretschmann, S. et al. (2023) ‘Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus’, Transplantation and Cellular Therapy, 29(1), pp. 27–33. Available at: https://doi.org/10.1016/j.jtct.2022.10.004.
Matthe, D.M. et al. (2023) ‘Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease’, Frontiers in Immunology, 14, p. 1253514. Available at: https://doi.org/10.3389/fimmu.2023.1253514.
Müller, F. et al. (2023) ‘CD19-targeted CAR T cells in refractory antisynthetase syndrome’, The Lancet, 401(10379), pp. 815–818. Available at: https://doi.org/10.1016/S0140-6736(23)00023-5.
Reimann, H. et al. (2023) ‘Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains’, Immunobiology, 228(5), p. 152720. Available at: https://doi.org/10.1016/j.imbio.2023.152720.
Salihoglu, R. et al. (2023a) ‘PRO-Simat: Protein network simulation and design tool’, Computational and Structural Biotechnology Journal, 21, pp. 2767–2779. Available at: https://doi.org/10.1016/j.csbj.2023.04.023.
Scheidler, L. et al. (2023) ‘Intestinal IgA-positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both graft-versus-host disease and relapse-related mortality’, Haematologica, 108(11), pp. 2993–3000. Available at: https://doi.org/10.3324/haematol.2022.282188.
Schett, G., Mackensen, A. and Mougiakakos, D. (2023) ‘CAR T-cell therapy in autoimmune diseases’, The Lancet, 402(10416), pp. 2034–2044. Available at: https://doi.org/10.1016/S0140-6736(23)01126-1.
Seal, R. et al. (2023) ‘Delayed and limited administration of the JAKinib tofacitinib mitigates chronic DSS-induced colitis’, Frontiers in Immunology, 14, p. 1179311. Available at: https://doi.org/10.3389/fimmu.2023.1179311.
Seefried, M. et al. (2023) ‘Murine cytomegalovirus reactivation concomitant with acute graft-versus-host disease is controlled by antibodies’, JCI Insight, 8(5), p. e149648. Available at: https://doi.org/10.1172/jci.insight.149648.
Siegmund, D. and Wajant, H. (2023) ‘TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond’, Nature Reviews Rheumatology, 19(9), pp. 576–591. Available at: https://doi.org/10.1038/s41584-023-01002-7.
Siegmund, D., Zaitseva, O. and Wajant, H. (2023) ‘Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling’, Frontiers in Cell and Developmental Biology, 11, p. 1267837. Available at: https://doi.org/10.3389/fcell.2023.1267837.
Stein-Thoeringer, C.K. et al. (2023a) ‘A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy’, Nature Medicine, 29(4), pp. 906–916. Available at: https://doi.org/10.1038/s41591-023-02234-6.
Stein-Thoeringer, C.K. et al. (2023b) ‘A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy’, Nature Medicine, 29(4), pp. 906–916. Available at: https://doi.org/10.1038/s41591-023-02234-6.
Thomas, S. and Abken, H. (2023) ‘CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells’, Frontiers in Immunology, 13, p. 1090959. Available at: https://doi.org/10.3389/fimmu.2022.1090959.
Thougaard, E. et al. (2023) ‘Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke’, Journal of Neuroimmunology, 385, p. 578246. Available at: https://doi.org/10.1016/j.jneuroim.2023.578246.
Treutlein, C. et al. (2023) ‘Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT’, European Journal of Nuclear Medicine and Molecular Imaging, 50(6), pp. 1629–1635. Available at: https://doi.org/10.1007/s00259-022-06081-4.
Weber, D., Weber, M., et al. (2023) ‘Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use’, Blood Advances, 7(7), pp. 1326–1335. Available at: https://doi.org/10.1182/bloodadvances.2022008480.
Weber, D., Hiergeist, A., et al. (2023) ‘Restrictive Versus Permissive Use of Broad-spectrum Antibiotics in Patients Receiving Allogeneic Stem Cell Transplantation and With Early Fever Due to Cytokine Release Syndrome: Evidence for Beneficial Microbiota Protection Without Increase in Infectious Complications’, Clinical Infectious Diseases, 77(10), pp. 1432–1439. Available at: https://doi.org/10.1093/cid/ciad389.
Youn, C. et al. (2023) ‘Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against Staphylococcus aureus’, Science Advances, 9(24), p. eadf8748. Available at: https://doi.org/10.1126/sciadv.adf8748.
Zaitseva, O. et al. (2023) ‘Basic characterization of antibodies targeting receptors of the tumor necrosis factor receptor superfamily’, Frontiers in Immunology, 14, p. 1115667. Available at: https://doi.org/10.3389/fimmu.2023.1115667.
2022
Bencurova, E. et al. (2022) ‘Nanocellulose Composites as Smart Devices With Chassis, Light-Directed DNA Storage, Engineered Electronic Properties, and Chip Integration’, Frontiers in Bioengineering and Biotechnology, 10, p. 869111. Available at: https://doi.org/10.3389/fbioe.2022.869111.
Bittner, S. et al. (2022) ‘Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy’, Proceedings of the National Academy of Sciences, 119(40), p. e2208436119. Available at: https://doi.org/10.1073/pnas.2208436119.
Böttcher, M. et al. (2022) ‘Bone marrow stroma cells promote induction of a chemoresistant and prognostic unfavorable S100A8/A9high AML cell subset’, Blood Advances, 6(21), pp. 5685–5697. Available at: https://doi.org/10.1182/bloodadvances.2021005938.
Caliskan, A. et al. (2022) ‘Progeria and Aging—Omics Based Comparative Analysis’, Biomedicines, 10(10), p. 2440. Available at: https://doi.org/10.3390/biomedicines10102440.
Cuvelier, G.D.E. et al. (2022) ‘Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force’, Transplantation and Cellular Therapy, 28(8), pp. 426–445. Available at: https://doi.org/10.1016/j.jtct.2022.05.038.
Decking, S.-M. et al. (2022) ‘LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid’, International Journal of Molecular Sciences, 23(11), p. 5970. Available at: https://doi.org/10.3390/ijms23115970.
Fathy, M. et al. (2022a) ‘Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats’, Biomedicines, 10(7), p. 1620. Available at: https://doi.org/10.3390/biomedicines10071620.
Fathy, M. et al. (2022b) ‘Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats’, Biomedicines, 10(7), p. 1620. Available at: https://doi.org/10.3390/biomedicines10071620.
Ghimire, S. et al. (2022) ‘Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation’, Frontiers in Immunology, 13, p. 857400. Available at: https://doi.org/10.3389/fimmu.2022.857400.
Gupta, S.K. et al. (2022) ‘Role of the Pangolin in Origin of SARS-CoV-2: An Evolutionary Perspective’, International Journal of Molecular Sciences, 23(16), p. 9115. Available at:
https://doi.org/10.3390/ijms23169115.
Harrer, D.C., Heidenreich, M., et al. (2022) ‘Apheresis for chimeric antigen receptor T‐cell production in adult lymphoma patients’, Transfusion, 62(8), pp. 1602–1611. Available at: https://doi.org/10.1111/trf.17030.
Harrer, D.C., Schenkel, C., et al. (2022) ‘Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells’, Cancers, 14(20), p. 5033. Available at: https://doi.org/10.3390/cancers14205033.
Lammoglia Cobo, M.F. et al. (2022) ‘Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL’, PLOS Pathogens. Edited by M.A. Luftig, 18(4), p. e1010206. Available at: https://doi.org/10.1371/journal.ppat.1010206.
Mackensen, A. et al. (2022) ‘Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus’, Nature Medicine, 28(10), pp. 2124–2132. Available at: https://doi.org/10.1038/s41591-022-02017-5.
Matos, C., Peter, K., et al. (2022) ‘Anti-Thymocyte Globulin Treatment Augments 1,25-Dihydroxyvitamin D3 Serum Levels in Patients Undergoing Hematopoietic Stem Cell Transplantation’, Frontiers in Immunology, 12, p. 803726. Available at: https://doi.org/10.3389/fimmu.2021.803726.
Matos, C., Mamilos, A., et al. (2022) ‘Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation’, Frontiers in Immunology, 13, p. 1028850. Available at: https://doi.org/10.3389/fimmu.2022.1028850.
Matos, C., Renner, K., et al. (2022) ‘Physiological levels of 25‐hydroxyvitamin D 3 induce a suppressive CD4 + T cell phenotype not reflected in the epigenetic landscape’, Scandinavian Journal of Immunology, 95(5), p. e13146. Available at: https://doi.org/10.1111/sji.13146.
Medler, J. et al. (2022) ‘CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism’, Theranostics, 12(4), pp. 1486–1499. Available at: https://doi.org/10.7150/thno.66119.
Medler, J., Kucka, K. and Wajant, H. (2022a) ‘Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy’, Cancers, 14(11), p. 2603. Available at: https://doi.org/10.3390/cancers14112603.
Medler, J., Kucka, K. and Wajant, H. (2022b) ‘Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy’, Cancers, 14(11), p. 2603. Available at: https://doi.org/10.3390/cancers14112603.
Meedt, E. et al. (2022) ‘Prolonged Suppression of Butyrate-Producing Bacteria Is Associated With Acute Gastrointestinal Graft-vs-Host Disease and Transplantation-Related Mortality After Allogeneic Stem Cell Transplantation’, Clinical Infectious Diseases, 74(4), pp. 614–621. Available at: https://doi.org/10.1093/cid/ciab500.
Orberg, E.T. et al. (2022) ‘Identification of Protective, Metabolite-producing Bacterial and Viral Consortia in Allogeneic Stem Cell Transplantation Patients’. Available at: https://doi.org/10.21203/rs.3.rs-1504704/v1.
Prada, J.P. et al. (2022) ‘Estimation of R0 for the spread of SARS-CoV-2 in Germany from excess mortality’, Scientific Reports, 12(1), p. 17221. Available at: https://doi.org/10.1038/s41598-022-22101-7.
Richter, S. et al. (2022) ‘The metabolic profile of reconstituting T-cells, NK-cells, and monocytes following autologous stem cell transplantation and its impact on outcome’, Scientific Reports, 12(1), p. 11406. Available at: https://doi.org/10.1038/s41598-022-15136-3.
Sarukhanyan, E., Shanmugam, T.A. and Dandekar, T. (2022) ‘In Silico Studies Reveal Peramivir and Zanamivir as an Optimal Drug Treatment Even If H7N9 Avian Type Influenza Virus Acquires Further Resistance’, Molecules, 27(18), p. 5920. Available at: https://doi.org/10.3390/molecules27185920.
Schmidt, A. et al. (2022) ‘Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling’, Frontiers in Cardiovascular Medicine, 9, p. 877450. Available at: https://doi.org/10.3389/fcvm.2022.877450.
Shaikh, H. et al. (2022) ‘Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells’, JCI Insight, 7(22), p. e154250. Available at: https://doi.org/10.1172/jci.insight.154250.
Ullrich, E., Beilhack, A. and Wolf, D. (2022) ‘Editorial: Novel and Improved Methods for the Prevention and Treatment of Graft-Versus-Host Disease (GVHD)’, Frontiers in Immunology, 13, p. 966389. Available at: https://doi.org/10.3389/fimmu.2022.966389.
Vargas, J.G. et al. (2022) ‘A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity’, Frontiers in Immunology, 13, p. 888274. Available at: https://doi.org/10.3389/fimmu.2022.888274.
2021
Kreft A, Hippe K, Wagner-Drouet EM, Ries I, Kandulski A, Büttner-Herold M, Neumann H, Weber D, Holler E, Schindeldecker M. An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease. PLoS One 2021 Aug 26;16(8):e0256543. doi: 10.1371/journal.pone.0256543. eCollection 2021.
Mougiakakos D, Bach C, Böttcher M, Beier F, Röhner L, Stoll A, Rehli M, Gebhard C, Lischer C, Eberhardt M, Vera J, Büttner-Herold M, Bitterer K, Balzer H, Leffler M, Jitschin S, Hundemer M, Awwad MHS, Busch M, Stenger S, Völkl S, Schütz C, Krönke J, Mackensen A, Bruns H. The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages. Cancer Immunol Res. 2021 Mar;9(3):265-278. doi: 10.1158/2326-6066.CIR-20-0555. Epub 2021 Feb 9.
Shaikh H, Vargas JG, Mokhtari Z, Jarick KJ, Ulbrich M, Mosca JP, Viera EA, Graf C, Le DD, Heinze KG, Büttner-Herold M, Rosenwald A, Pezoldt J, Huehn J, Beilhack A. Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Front Immunol. 2021 Jul 26;12:689896. doi: 10.3389/fimmu.2021.689896. eCollection 2021.
Shaikh H, Vargas JG, Mokhtari Z, Jarick KJ, Ulbrich M, Mosca JP, Viera EA, Graf C, Le DD, Heinze KG, Büttner-Herold M, Rosenwald A, Pezoldt J, Huehn J, Beilhack A. Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Front Immunol. 2021 Jul 26;12:689896. doi: 10.3389/fimmu.2021.689896. eCollection 2021.
Ferreira-Gomes M, Kruglov A, Durek P, Heinrich F, Tizian C, Heinz GA, Pascual-Reguant A, Du W, Mothes R, Fan C, Frischbutter S, Habenicht K, Budzinski L, Ninnemann J, Jani PK, Guerra GM, Lehmann K, Matz M, Ostendorf L, Heiberger L, Chang HD, Bauherr S, Maurer M, Schönrich G, Raftery M, Kallinich T, Mall MA, Angermair S, Treskatsch S, Dörner T, Corman VM, Diefenbach A, Volk HD, Elezkurtaj S, Winkler TH, Dong J, Hauser AE, Radbruch H, Witkowski M, Melchers F, Radbruch A, Mashreghi MF. SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself. Nat Commun. 2021;12(1):1961. doi: 10.1038/s41467-021-22210-3.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K.J. Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone. Clin Invest 2021 Nov 15;131(22):e148225. doi: 10.1172/JCI148225.PMID: 34779418
Ghimire S, Weber D, Hippe K, Meedt E, Hoepting M, Kattner AS, Hiergeist A, Gessner A, Matos C, Ghimire S, Wolff D, Edinger M, Hoffmann P, Poeck H, Herr W, Holler E. GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. Front Immunol. 2021 Oct 28;12:753287. doi: 10.3389/fimmu.2021.753287. eCollection 2021.PMID: 34777363.
Rayamajhi Thapa R, Plentz A, Edinger M, Wolff D, Angstwurm K, Söderlund-Venermo M. Human bocavirus 1 respiratory tract reactivations or reinfections in two adults, contributing to neurological deficits and death.
Access Microbiol. 2021 Jul 8;3(7):000237. doi: 10.1099/acmi.0.000237. eCollection 2021.PMID: 34595389.
Sattler C, Hoffmann P, Herzberg PY, Weber D, Holler B, Fehn U, Plentz A, Beckhove P, Winkler J, Edinger M, Herr W, Holler E, Wolff D. Primary vaccination in adult patients after allogeneic hematopoietic stem cell transplantation - A single center retrospective efficacy analysis.
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Pausch AM, Kammerer S, Weber F, Herr W, Stroszczynski C, Holler E, Edinger M, Wolff D, Weber D, Jung EM, Wertheimer T. Parametric Imaging of Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Acute Gastrointestinal Graft-Versus-Host Disease. Cells 2021 May 3;10(5):1092. doi: 10.3390/cells10051092.PMID: 34063640.
Wertheimer T, Dohse M, Afram G, Weber D, Heidenreich M, Holler B, Kattner AS, Neubauer A, Mielke S, Ljungman P, Holler E, Herr W, Edinger M, Martínez AP, Fante M, Wolff D. Abatacept as salvage therapy in chronic graft-versus-host disease-a retrospective analysis. Ann Hematol. 2021 Mar;100(3):779-787. doi: 10.1007/s00277-021-04434-x. Epub 2021 Jan 30.PMID: 33515310.
Ronin E, Pouchy C, Khosravi M, Hilaire M, Grégoire S, Casrouge A, Kassem S, Sleurs D, Martin GH, Chanson N, Lombardi Y, Lalle G, Wajant H, Auffray C, Lucas B, Marodon G, Grinberg-Bleyer Y, Salomon BL. Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells. Proc Natl Acad Sci U S A 2021 Mar 30;118(13):e2014043118. doi: 10.1073/pnas.2014043118.
Kucka K, Lang I, Zhang T, Siegmund D, Medler J, Wajant H. Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist. Cell Death Dis. 2021 Apr 6;12(4):360. doi: 10.1038/s41419-021-03633-8.
Prada JP, Wangorsch G, Kucka K, Lang I, Dandekar T, Wajant H. A systems-biology model of the tumor necrosis factor (TNF) interactions with TNF receptor 1 and 2. Bioinformatics 2021 May 5;37(5):669-676. doi: 10.1093/bioinformatics/btaa844
Da Vià MC, Dietrich O, Truger M, Arampatzi P, Duell J, Heidemeier A, Zhou X, Danhof S, Kraus S, Chatterjee M, Meggendorfer M, Twardziok S, Goebeler ME, Topp MS, Hudecek M, Prommersberger S, Hege K, Kaiser S, Fuhr V, Weinhold N, Rosenwald A, Erhard F, Haferlach C, Einsele H, Kortüm KM, Saliba AE, Rasche L. Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma. Nat Med 2021 27(4):616-9.
Delacher M, Simon S, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Schmidleithner L, Bittner S, Pant A, Ritter U, Hehlgans T, Riegel D, Schneider V, Groeber-Becker FK, Eigenberger A, Gebhard C, Strieder N, Fischer A, Rehli M, Hoffmann P, Edinger M, Strowig T, Huehn J, Schmidl C, Werner JM, Prantl L, B Brors B, Imbusch CD, Feuerer M. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity 2021;54:702-720.
Prommersberger S, Reiser M, Beckmann J, Danhof S, Amberger M, Quade-Lyssy P, Einsele H, Hudecek M, Bonig H, Ivics Z. CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma. Gene Ther. 2021. doi: 10.1038/s41434-021-00254-w. Online ahead of print.
Reimann H*, Nguyen A*, Sanborn JZ, Vaske CJ, Benz S, Niazi K, Rabizadeh S, Spilman P, Mackensen A, Ruebner M, Hein A, Beckmann MW, van der Meijden ED, Bausenwein J, Kretschmann S, Griffioen M, Schlom J, Gulley JL, Lee KL, Hamilton DH, Soon-Shiong P, Fasching PA*, Kremer AN*. Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy. J Immunother Cancer, 2021 Jun;9(6):e002605.
Peter K, Siska PJ, Roider T, Matos C, Bruns H, Renner K, Singer K, Weber D, Güllstorf M, Kröger N, Wolff D, Herr W, Ayuk F, Holler E, Stark K, Heid IM, Kreutz M. 1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation. Bone Marrow Transplant 2021 Feb;56:419-33.
Niehus S, Jónsson H, Schönberger J, Björnsson E, Beyter D, Eggertsson HP, Sulem P, Stefánsson K, Halldórsson BV, Kehr B. PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes. Nat Commun 2021;12:730.
Meedt E, Hiergeist A, Gessner A, Dettmer K, Liebisch G, Ghimire S, Poeck H, Edinger M, Wolff D, Herr W, Holler E, Weber D. Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation. Clinical Infectious Diseases 2021, May 27:ciab500. doi: 10.1093/cid/ciab500.
Majumder S, Jugovic I, Saul D, Bell L, Hundhausen N, Seal R, Beilhack A, Rosenwald A, Mougiakakos D, Berberich-Siebelt F. Rapid and efficient gene editing for direct transplantation of naive murine Cas9 + T cells. Front Immunol 2021, doi: 10.3389/fimmu.2021.683631
Karl F, Stoll A, Böttcher-Loschinski R, Böttcher M, Baur R, Jacobs B, Völkl S, Jitschin R, Rösler W, Mackensen A, Mougiakakos D. Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients. Leukemia 2021;35:910-5.
Bernhardt AL*, Marecek M*, Reimann H, Kretschmann S, Bausenwein J, van der Meijden ED, Karg, MM, Haug T, Meintker L, Lutzny-Geier G, Mackensen A, Kremer AN. Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens. J Immunother Cancer;9(7):e002401.
Jetani H, Navarro-Bailón A, Frenz S, Maucher M, Verbruggen C, Yeguas A, Belén Vidriales M, González M, Rial Saborido J, Kraus S, Mestermann K, Thomas S, Bönig H, Luu M, Monjezi R, Mougiakakos D, Sauer M, Einsele H. Hudecek M. Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia (AML). Blood. 2021;2020009192
Bäuerlein CA, Qureischi M, Mokhtari Z, Tabares P, Brede C, Jordán Garrote AL, Riedel SS, Chopra M, Reu S, Mottok A, Arellano-Viera E, Graf C, Kurzwart M, Schmiedgen K, Einsele H, Wölfl M, Schlegel PG, Beilhack A. A T-cell surface marker panel predicts murine acute graft-versus-host disease. Front Immunol. 2021;11:593321.
Xiao Y*, Qureischi M*, Dietz L*, Vaeth M, Vallabhapurapu SD, Klein-Hessling S, Klein M, Liang C, Konig A, Serfling E, Mottok A, Bopp T, Rosenwald A, Buttmann M, Berberich I, Beilhack A, Berberich-Siebelt F. Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity. J Exp Med 2021;218:1-22.
Xydia M*, Rahbari R*, Ruggiero E*, Macaulay I, Tarabichi M, Lohmayer R, Wilkening S, Michels T, Daniel Brown D, Vanuytven S, Mastitskaya S, Laidlaw S, Grabe N, Pritsch M, Fronza R, Hexel K, Schmitt S, Müller-Steinhardt M, Halama N, Domschke C, Schmidt M, von Kalle C, Schütz F, Voet T, Beckhove P. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. Nat Commun 2021;12:1119.
Zhang Y, Shen L, Dreißigacker K, Zhu H, Trinh-Minh T, Meng X, Tran-Manh C, Dees C, Matei A-E, Chen C-W, Ditschkowski M, Krauss S, Winkler J, Wolff D, Ziemer M, Beilhack A, Karrer S, Herr W, Mackensen A, Schett G, Spriewald BM, Distler JHW. Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease. Blood. 2021;blood.2020008720. doi: 10.1182/blood.2020008720.
2020
Delacher M, Imbusch CD, Hotz-Wagenblatt A, Mallm JP, Bauer K, Simon M, Riegel D, Rendeiro AF, Bittner S, Sanderink L, Pant A, Schmidleithner L, Braband KL, Echtenachter B, Fischer A, Giunchiglia V, Hoffmann P, Edinger M, Bock C, Rehli M, Brors B, Schmidl C*, Feuerer M*. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Immunity 2020;52:295-312.
Strauch V, Saul D, Berisha M, Mackensen A, Mougiakakos D*, Jitschin R*. N-glycosylation controls inflammatory licensing-triggered PD-L1 upregulation in human mesenchymal stromal cells. Stem Cells 2020;38:986-93.
Kunz M, Wolf B, Fuchs M, Christoph J, Xiao K, Thum T, Atlan D, Prokosch HU, Dandekar T. A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs. Brief Bioinform 2020;21:1391-96.
Volpin V, Michels T, Sorrentino A, Menevse AN, Knoll G, Ditz M, Milenkovic VM, Chen CY, Rathinasamy A, Griewank K, Boutros M, Haferkamp S, Berneburg M, Wetzel CH, Seckinger A, Hose D, Goldschmidt H, Ehrenschwender M, Witzens-Harig M, Szoor A, Vereb G, Khandelwal N, Beckhove P. CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment. Cancer Immunol Res 2020;8:1163-79.
Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. Blood 2020;136:130-6.
Klobuch S, Hammon K, Vatter-Leising S, Neidlinger E, Zwerger M, Wandel A, Neuber LM, Heilmeier B, Fichtner R, Mirbeth C, Herr W, Thomas S. HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation. Cells 2020;9:1264.
Rasche L, Hudecek M, Einsele H. What is the future of immunotherapy in multiple myeloma? Blood. 2020;136(22):2491-7.
Riegel C, Boeld TJ, Doser K, Huber E, Hoffmann P, Edinger M. Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells. Leukemia 2020;34:895-908.
Gudipati V, Rydzek J, Doel-Perez I, Gonçalves VDR, Scharf L, Königsberger S, Lobner E, Kunert R, Einsele H, Stockinger H, Hudecek M*, Huppa JB*. Inefficient CAR-proximal signaling blunts antigen sensitivity. Nat Immunol 2020;21:848-56.
Prada JP, Wangorsch G, Kucka K, Lang I, Dandekar T, Wajant H. A systems-biology model of the tumor necrosis factor (TNF) interactions with TNF receptor 1 and 2. Bioinformatics 2020;btaa844.
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623
Knop J, Spilgies LM, Rufli S, Reinhart R, Vasilikos L, Yabal M, Owsley E, Jost PJ, Marsh RA, Wajant H, Robinson MD, Kaufmann T, Wong WW. Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP. Cell Death Dis. 2020 Jan 23;11(1):56. doi: 10.1038/s41419-020-2261-2.
Naseem M, Osmanoglu Ö, Dandekar T. Synthetic Rewiring of Plant CO2 Sequestration Galvanizes Plant Biomass Production. Trends Biotechnol. 2020 Jan 17. pii: S0167-7799(19)30314-2. doi: 10.1016/j.tibtech.2019.12.019. [Epub ahead of print]
Delacher M, Imbusch CD, Hotz-Wagenblatt A, Mallm JP, Bauer K, Simon M, Riegel D, Rendeiro AF, Bittner S, Sanderink L, Pant A, Schmidleithner L, Braband KL, Echtenachter B, Fischer A, Giunchiglia V, Hoffmann P, Edinger M, Bock C, Rehli M, Brors B, Schmidl C, Feuerer M. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Immunity. 2020 Jan 2. pii: S1074-7613(19)30498-4. doi: 10.1016/j.immuni.2019.12.002. [Epub ahead of print]
Soare A, Györfi HA, Matei AE, Dees C, Rauber S, Wohlfahrt T, Chen CW, Ludolph I, Horch RE, Bäuerle T, von Hörsten S, Mihai C, Distler O, Ramming A, Schett G, Distler JHW. Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis. Arthritis Rheumatol. 2020 Jan;72(1):137-149. doi: 10.1002/art.41058.
2019
Wagner-Drouet E, Teschner D, Wolschke C, Janson D, Schäfer-Eckart K, Gärtner J, Mielke S, Schreder M, Kobbe G, Kondakci M, Hilgendorf I, von Lilienfeld-Toal M, Klein S, Heidenreich D, Kreil S, Verbeek M, Graß S, Ditschkowski M, Gromke T, Koch M, Lindemann M, Hünig T, Schmidt T, Rascle A, Guldan H, Barabas S, Deml L, Wagner R, Wolff D. Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation. Haematologica. 2019 Dec 26. pii: haematol.2019.229252. doi: 10.3324/haematol.2019.229252. [Epub ahead of print]
Srinagesh HK, Özbek U, Kapoor U, Ayuk F, Aziz M, Ben-David K, Choe HK, DeFilipp Z, Etra A, Grupp SA, Hartwell MJ, Hexner EO, Hogan WJ, Karol AB, Kasikis S, Kitko CL, Kowalyk S, Lin JY, Major-Monfried H, Mielke S, Merli P, Morales G, Ordemann R, Pulsipher MA, Qayed M, Reddy P, Reshef R, Rösler W, Sandhu KS, Schechter T, Shah J, Sigel K, Weber D, Wölfl M, Wudhikarn K, Young R, Levine JE, Ferrara JLM. The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease. Blood Adv. 2019 Dec 10;3(23):4034-4042. doi: 10.1182/bloodadvances.2019000791
Banaszek A, Bumm TGP, Nowotny B, Geis M, Jacob K, Wölfl M, Trebing J, Kucka K, Kouhestani D, Gogishvili T, Krenz B, Lutz J, Rasche L, Hönemann D, Neuweiler H, Heiby JC, Bargou RC, Wajant H, Einsele H, Riethmüller G6, Stuhler G7. On-target restoration of a split T cell-engaging antibody for precision immunotherapy. Nat Commun. 2019 Nov 26;10(1):5387. doi: 10.1038/s41467-019-13196-0.
Delacher M, Schmidl C, Herzig Y, Breloer M, Hartman W, Brunk F, Kägebein D, Träger U, Hofer AC, Weichenhan D, Imbusch CD, Hotz-Wagenblatt A, Hielscher T, Breiling A, Federico G, Gröne HJ, Schmid RM, Rehli M, Abramson J, Feuerer M. Rbpj expression in regulatory T cells is critical for restraining TH2 responses. Nat Commun 2019;10:1621.
Harrer DC, Schuler G, Dörrie J, Schaft N. CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia. Int J Mol Sci 2019;20,2764.
Jitschin R, Böttcher M, Saul D, Lukassen S, Bruns H, Loschinski R, Ekici AB, Reis A, Mackensen A, Mougiakakos D. Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation. Leukemia 2019;33:1783-96.
Heidegger S*, Wintges A *, Stritzke F, Bek S, Steiger K, Koenig PA, Göttert S, Engleitner T, Öllinger R, Nedelko T, Fischer JC, Makarov V, Winter C, Rad R, van den Brink MRM, Ruland J, Bassermann F, Chan TA, Haas T*, Poeck H*. RIG-I activation is critical for responsiveness to checkpoint blockade. Sci Immunol 2019;4:eaau8943.
Querques I, Mades A, Zuliani C, Miskey C, Alb M, Grueso E, Machwirth M, Rausch T, Einsele H, Ivics Z, Hudecek M*, Barabas O*. A highly soluble Sleeping Beauty transposase improves control of gene insertion. Nat Biotechnol 2019;37:1502-12.
Mestermann K, Giavridis T, Weber J, Rydzek J, Frenz S, Nerreter T, Mades A, Sadelain M, Einsele H, Hudecek M. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Sci Transl Med 2019; 11:eaau5907.
Fathy M, Fawzy MA, Hintzsche H, Nikaido T, Dandekar T, Othman EM. Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation. Molecules. 2019 Nov 3;24(21). pii: E3979. doi: 10.3390/molecules24213979.
Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science. 2019 Nov 29;366(6469):1143-1149. doi: 10.1126/science.aax3760.
Flamann C, Peter K, Kreutz M, Bruns H. Regulation of the Immune Balance During Allogeneic Hematopoietic Stem Cell Transplantation by Vitamin D. Front Immunol. 2019 Nov 5;10:2586. doi: 10.3389/fimmu.2019.02586. eCollection 2019.
Thiagarajan S, Neurath MF, Hildner K. Resolution of acute intestinal graft-versus-host disease. Semin Immunopathol. 2019 Nov;41(6):655-664. doi: 10.1007/s00281-019-00769-w. Epub 2019 Oct 31.
Matei AE, Chen CW, Kiesewetter L, Györfi AH, Li YN, Trinh-Minh T, Xu X, Tran Manh C, van Kuppevelt T, Hansmann J, Jüngel A, Schett G, Groeber-Becker F, Distler JHW. Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Ann Rheum Dis. 2019 Dec;78(12):1686-1692. doi: 10.1136/annrheumdis-2019-216108. Epub 2019 Sep 20.
Wajant H, Beilhack A. Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer. Front Immunol. 2019 Aug 28;10:2040. doi: 10.3389/fimmu.2019.02040. eCollection 2019.
Klobuch S, Weber D, Holler B2, Edinger M, Herr W, Holler E, Wolff D. Long-term follow-up of rituximab in treatment of chronic graft-versus-host disease-single center experience. Ann Hematol. 2019 Oct;98(10):2399-2405. doi: 10.1007/s00277-019-03768-x. Epub 2019 Aug 3.
Kretschmann S, Herda S, Bruns H, Russ J, van der Meijden ED, Schlötzer-Schrehardt U4, Griffioen M3, Na IK2,5,6,7, Mackensen A1, Kremer AN1. Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY. J Clin Invest. 2019 Jun 17;129(7):2952-2963. doi: 10.1172/JCI123105. eCollection 2019 Jun 17.
Liang R, Kagwiria R, Zehender A, Dees C, Bergmann C, Ramming A, Krasowska D, Michalska-Jakubus M, Kreuter A, Kraner ME, Schett G, Distler JHW. Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc. Ann Rheum Dis. 2019 Sep;78(9):1269-1273. doi: 10.1136/annrheumdis-2019-215066. Epub 2019 Jun 8.
Wajant H, Siegmund D. TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages. Front Cell Dev Biol. 2019 May 29;7:91. doi: 10.3389/fcell.2019.00091. eCollection 2019.
Haug T, Aigner M, Peuser MM, Strobl CD, Hildner K, Mougiakakos D, Bruns H, Mackensen A, Völkl S. Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity. Front Immunol. 2019 Apr 26;10:883. doi: 10.3389/fimmu.2019.00883. eCollection 2019
Medler J, Wajant H. Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target. Expert Opin Ther Targets. 2019 Apr;23(4):295-307. doi: 10.1080/14728222.2019.1586886. Epub 2019 Mar 19.
Medler J, Nelke J, Weisenberger D, Steinfatt T, Rothaug M, Berr S, Hünig T, Beilhack A, Wajant H. TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity. Cell Death Dis. 2019 Mar 4;10(3):224. doi: 10.1038/s41419-019-1456-x.
Buchele V, Büttner-Herold M, Vogler T, Neurath MF, Hildner K. Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice. J Vis Exp. 2019 Feb 11;(144). doi: 10.3791/58871.
Haug T, Aigner M, Peuser MM, Strobl CD, Hildner K, Mougiakakos D, Bruns H, Mackensen A, Völkl S. Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity. Front Immunol. 2019;10:883.
Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL, Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A. PU.1 controls fibroblast polarization and tissue fibrosis. Nature. 2019 Feb;566(7744):344-349. doi: 10.1038/s41586-019-0896-x. Epub 2019 Jan 30.
Flamann C, Busch L, Mackensen A, Bruns H. Combination of lenalidomide and vitamin D enhances MOR202-mediated cytotoxicity of macrophages: It takes three to tango. Oncotarget. 2019 Jan 1;10(1):10-12. doi: 10.18632/oncotarget.26531. eCollection 2019 Jan 1.
2018
Siegmund D, Ehrenschwender M, Wajant H. TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling. Cell Death Dis. 2018 Sep 11;9(9):921. doi: 10.1038/s41419-018-0973-3.
Lang I, Füllsack S, Wajant H. Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies. Front Immunol. 2018 Apr 23;9:793. doi: 10.3389/fimmu.2018.00793. eCollection 2018.
Buchele V, Abendroth B, Büttner-Herold M, Vogler T, Rothamer J, Ghimire S, Ullrich E, Holler E, Neurath MF, Hildner K. Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis. Front Immunol. 2018;9:1138.
Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K. BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease. J Clin Invest. 2018;128(3):916-930.
Jitschin R, Böttcher M, Saul D, Lukassen S, Bruns H, Loschinski R, Ekici AB, Reis A, Mackensen A, Mougiakakos D. Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation. Leukemia. 2019. doi: 10.1038/s41375-018-0376-6. [Epub ahead of print]
Böttcher M, Renner K, Berger R, Mentz K, Thomas S, Cardenas-Conejo ZE, Dettmer K, Oefner PJ, Mackensen A, Kreutz M, Mougiakakos D. D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. Oncoimmunology. 2018;7(7):e1445454.
Loschinski R, Böttcher M, Stoll A, Bruns H, Mackensen A, Mougiakakos D. IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner. Oncotarget. 2018;9(17):13125-13138.
Weber D, Hiergeist A, Weber M, Dettmer K, Wolff D, Hahn J, Herr W, Gessner A, Holler E. Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics. Clin Infect Dis. 2018. doi: 10.1093/cid/ciy711. [Epub ahead of print]
Siegmund D, Ehrenschwender M, Wajant H. TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling. Cell Death Dis. 2018;9(9):921.
Lang I, Füllsack S, Wajant H. Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies. Front Immunol. 2018;9:793.
Medler J, Nelke J, Weisenberger D, Steinfatt T, Rothaug M, Berr S, Hünig T, Beilhack A, Wajant H. TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity. Cell Death Dis. 2019;10(3):224.
Jarick KJ, Mokhtari Z, Scheller L, Hartweg J, Thusek S, Le DD, Ranecky M, Shaikh H, Qureischi M, Heinze KG, Beilhack A. Photoconversion of Alloreactive T Cells in Murine Peyer's Patches During Acute Graft-Versus-Host Disease: Tracking the Homing Route of Highly Proliferative Cells In Vivo. Front Immunol. 2018;9:1468.
Busch L1, Mougiakakos D1, Büttner-Herold M2, Müller MJ3, Volmer DA3, Bach C1, Fabri M4, Bittenbring JT5, Neumann F5, Boxhammer R6, Nolting J7, Bisht S7, Böttcher M1, Jitschin S1, Hoffmann MH8, Balzer H1, Beier F9, Gezer D9, Dudziak D10, Gelse K11, Hennig FF11, Pallasch CP12, Spriewald B1, Mackensen A1, Bruns H13. Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway Leukemia 2018; 2445-2458.
Flamann C1, Busch L1, Mackensen A1, Bruns H1. Combination of lenalidomide and vitamin D enhances MOR202-mediated cytotoxicity of macrophages: It takes three to tango. Oncotarget. 2019 Jan 1; 10-12. doi: 10.18632/oncotarget.26531. eCollection 2019 Jan 1.
Schmidl C, Delacher M, Huehn J, Feuerer M. Epigenetic mechanisms regulating T-cell responses. J Allergy Clin Immunol. 2018;142(3):728-743.
Weber D, Weber M, Hippe K, Ghimire S, Wolff D, Hahn J, Evert M, Herr W, Holler E, Jung EM. Non-invasive diagnosis of acute intestinal graft-versus-host disease by a new scoring system using ultrasound morphology, compound elastography, and contrast-enhanced ultrasound. Bone Marrow Transplant. 2018. doi: 10.1038/s41409-018-0381-4. [Epub ahead of print]
Solimando AG, Brandl A, Mattenheimer K, Graf C, Ritz M, Ruckdeschel A, Stühmer T, Mokhtari Z, Rudelius M, Dotterweich J, Bittrich M, Desantis V, Ebert R, Trerotoli P, Frassanito MA, Rosenwald A, Vacca A, Einsele H, Jakob F, Beilhack A. JAM-A as a prognostic factor and new therapeutic target in multiple myeloma. Leukemia. 2018;32(3):736-743.
Jetani H, Garcia-Cadenas I, Nerreter T, Thomas S, Rydzek J, Meijide JB, Bonig H, Herr W, Sierra J, Einsele H, Hudecek M. CAR T-cells targeting FLT3 have potent activity against FLT3-ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib. Leukemia. 2018 Feb 5. doi: 10.1038/s41375-018-0009-0. [Epub ahead of print]
2017
Fischer JC*, Bscheider M*, Eisenkolb G*, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM*,Poeck H*. RIG-I/MAVS and STING signaling promote gut integrity during irradiation and immune-medited tissue injury; Sci Transl Med 2017a;9:eaag2513.
Tittlbach H, Schneider A, Strobel J, Zimmermann R, Maas S, Gebhardt B, Rauser G, Mach M, Mackensen A, Winkler TH, Winkler J. GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation. J Transl Med. 2017;15(1):228.
Herr W*, Eichinger Y*, Beshay J*, Bloetz A*, Vatter S, Mirbeth C, Distler E, Hartwig UF, Thomas S. HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation. Leukemia. 2017;31(2):434-445.
Monjezi R, Miskey C, Gogishvili T, Schleef M, Schmeer M, Einsele H, Ivics Z, Hudecek M. Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors. Leukemia. 2017;31(1):186-194.
Delacher M, Imbusch CD, Weichenhan D, Breiling A, Hotz-Wagenblatt A, Träger U, Hofer AC, Kägebein D, Wang Q, Frauhammer F, Mallm JP, Bauer K, Herrmann C, Lang PA, Brors B, Plass C, Feuerer M. Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol. 2017;18(10):1160-1172.
Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, Dettmer K, Weber M, Wolff D, Hahn J, Pamer EG, Herr W, Gessner A, Oefner PJ, van den Brink MR, Holler E. Microbiota Disruption Induced by Early Use of Broad Spectrum Antibiotics is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017;23(5):845-852.
2016
Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH*, Nitschke L*. Siglec-H protects from virus-triggered severe systemic autoimmunity. J Exp Med. 2016;213(8):1627-1644.
Qorraj M, Bruns H, Böttcher M, Weigand L, Saul D, Mackensen A, Jitschin R, Mougiakakos D. The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia. Leukemia. 2016;31(2):470-478.
Braun M, Qorraj M, Büttner M, Klein FA, Saul D, Aigner M, Huber W, Mackensen A, Jitschin R, Mougiakakos D. CXCL12 promotes glycolytic reprogramming in acute myeloid leukemia cells via the CXCR4/mTOR axis. Leukemia. 2016;30(8):1788-1792.
Sommermeyer D*, Hudecek M*, Kosasih PL, Gogishvili T, Maloney DG, Turtle CJ, Riddell SR. Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo. Leukemia. 2016;30(2):492-500.
Viardot A, Goebeler ME, Hess G, Neumann S, Pfreundschuh M, Adrian N, Zettl F, Libicher M, Sayehli C, Stieglmaier J, Zhang A, Nagorsen D, Bargou RC. Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma. Blood. 2016;127(11):1410-1416.
Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán-Garrote AL, Bäuerlein CA, Brede C, Ribechini E, Fick A, Seher A, Polz J, Ottmüller KJ, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Müller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H*, Beilhack A*. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med. 2016;213(9):1881-1900.
Siegmund D, Kums J, Ehrenschwender M, Wajant H. Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis. 2016;7(9):e2375.
Grube M, Holler E, Weber D, Holler B, Herr W, Wolff D. Risk Factors and Outcome of Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation-Results from a Single-Center Observational Study. Biol Blood Marrow Transplant. 2016;22(10):1781–1791.
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K. Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer. Gut. 2016;65(7):1139-1150.
2015
Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase MJ*, Herr W*, Lemmermann N*. Evaluating human T-cell therapy of cytomegalovirus organ disease in HLA-transgenic mice. PLoS Pathog. 2015;11(7):e1005049.
Khandelwal N*, Breinig M*, Speck T, Michels T, Kreutzer C, Sorrentino A, Sharma AK, Umansky L, Conrad H, Poschke I, Offringa R, König R, Bernhard H, Machlenkin A, Boutros M, Beckhove P. A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes. EMBO Mol Med. 2015;7(4):450-463.
Vaeth M, Bäuerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, Rosenwald A, Beilhack A, Berberich-Siebelt F. Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. Proc Natl Acad Sci U S A. 2015;112(4):1125-1130.
Weber D, Oefner PJ, Hiergeist A, Koestler J, Gessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, Holler E. Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome. Blood. 2015;126(14):1723-1728.
Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein CA, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A*, Wajant H.* Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD. Blood. 2015;126(4):437-444.
Jitschin R, Braun M, Qorraj M, Saul D, Le Blanc K, Zenz T, Mougiakakos D. Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling. Blood. 2015;125(22):3432-3436.
Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH. Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis. Nat Med. 2015;21(2):150-158.
Cochain C, Koch M, Chaudhari SM, Busch M, Pelisek J, Boon L, Zernecke A. CD8+ T Cells Regulate Monopoiesis and Circulating Ly6Chigh Monocyte Levels in Atherosclerosis in Mice. Mice. Circ Res. 2015;117(3):244-253.
Bruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A. Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma. Sci Transl Med. 2015;7(282):282ra47.
Kreft A, Mottok A, Mesteri I, Cardona DM, Janin A, Kühl AA, Andrulis M, Brunner A, Shulman HM, Negri G, Tzankov A, Huber E. Gastrointestinal Pathology Group of the German-Austrian-Swiss GvHD Consortium. Consensus diagnostic histopathological criteria for acute gastrointestinal graft versus host disease improve interobserver reproducibility. Virchows Arch 2015;467:255-63.
2014
Topp MS, Gökbuget N, Zugmaier G, Klappers P, Stelljes M, Neumann S, Viardot A, Marks R, Diedrich H, Faul C, Reichle A, Horst HA, Brüggemann M, Wessiepe D, Holland C, Mergen N, Einsele H, Hoelzer D, Bargou RC. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows haematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol. 2014;32:4134-4140.
Kremer AN, van der Griendt JC, van der Meijden ED, Honders MW, Ayoglu B, Schwenk JM, Nilsson P, Falkenburg JH, Griffioen M. Development of a coordinated allo T-cell and auto B-cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation. Haematologica. 2014;99(2):365-369.
Jitschin R, Braun M, Büttner M, Dettmer-Wilde K, Bricks J, Berger J, Eckart MJ, Krause SW, Le Blanc K, Mackensen A, Mougiakakos D. CLL-cells induce IDOhi CD14+HLA-DRlo myeloid derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood. 2014;124(5):750-60.
Jitschin R, Hofmann AD, Bruns H, Giessl A, Bricks J, Berger J, Saul D, Eckart MJ, Mackensen A, Mougiakakos D. Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia. Blood. 2014;123(17):2663-2672.
Schmidl C, Hansmann L, Lassmann T, Balwierz PJ, Kawaji H, Itoh M, Kawai J, Nagao-Sato S, Suzuki H, Andreesen R, Hayashizaki Y, Forrest AR, Carninci P, Hoffmann P, Edinger M, Rehli M; FANTOM consortium. The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood. 2014;123(17):e68-78.
Vaeth M, Müller G, Stauss D, Dietz L, Klein-Hessling S, Serfling E, Lipp M, Berberich I, Berberich-Siebelt F. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med. 2014;211(3):545-561.
Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation. 2014;129(5):598-606.
Andersson R, Gebhard C*, et al., Rehli M*, Sandelin A. An atlas of active enhancers across human cell types and tissues. Nature. 2014;507(7493):455-461. *M Rehli´s PostDoc is co-first & MR co-corresponding author
2013
Klug F*, Prakash H*, Huber PE*, Seibel T*, Bender N, Halama N, Pfirschke C, Voss RH, Timke C, Umansky L, Klapproth K, Schäkel K, Garbi N, Jäger D, Weitz J, Schmitz-Winnenthal H, Hämmerling GJ, Beckhove P. Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell. 2013;24(5):589-602.
Levine JE, Huber E, Hammer ST, Harris AC, Greenson JK, Braun TM, Ferrara JL, Holler E. Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality. Blood 2013;122:1505-9.
Witzens-Harig M, Hose D, Jünger S, Pfirschke C, Khandelwal N, Umansky L, Seckinger A, Conrad H, Brackertz B, Rème T, Gueckel B, Meißner T, Hundemer M, Ho AD, Rossi JF, Neben K, Bernhard H, Goldschmidt H, Klein B, Beckhove P. Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6. Blood. 2013;121(22):4493-4503.
Hettinger J, Richards DM, Hansson J, Barra MM, Joschko AC, Krijgsveld J, Feuerer M. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol. 2013;14(8):821-830.
2012
Kremer AN, van der Meijden ED, Honders MW, Goemann JJ, Wiertz EJ, Falkenburg JH, Griffioen M. Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO. Blood 2012;120(16):3246-3255.
Zerr P, Palumbo-Zerr K, Distler A, Tomcik M, Vollath S, Munoz LE, Beyer C, Dees C, Egberts F, Tinazzi I, Del Galdo F, Distler O, Schett G, Spriewald BM, Distler JH. Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease. Blood. 2012;120(14):2909-2917.
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Müller MR, Serfling E, Sawitzki BS, Berberich-Siebelt F. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109(40):16258-16263.
Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, MacDougald OA, Distler O, Schett G, Distler JH. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun. 2012;3:735.
Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012;486(7404):549-553.
Brede C, Friedrich M, Jordán-Garrote AL, Riedel SS, Bäuerlein CA, Heinze K, Bopp T, Schulz S, Mottok A, Kiesel C, Mattenheimer K, Ritz M, von Krosigk V, Rosenwald A, Einsele H, Negrin RS, Harms GS, Beilhack A. Mapping immune processes in intact tissues at cellular resolution. 2012;122(12):4439-4446.
2011
Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Förster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011;121(7):2898-2910.
Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Huber E, Landfried K, Akashi K, Vander Lugt M, Reddy P, Chin A, Zhang Q, Hanash S, Paczesny S. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood 2011;118:6702-8.
Brenner S, Drewel D, Steinbart T, Weisel F, Härtel E, Pötzsch S, Welzel H, Brandl A, Yu P, Mudde GC, Schweizer A, Nitschke L, Winkler TH. A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO J. 2011;30(13):2705-2718.
2009
Stumpf AN, van der Meijden ED, van Bergen CA, Willemze R, Falkenburg JH, Griffioen M. Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity. Blood. 2009;114(17):3684-3692.
Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373(9674):1550-1561.
2008
Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008;322(5904):1097-1100.
Bargou RC, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, Noppeney R, Viardot A, Hess G, Schuler M, Einsele H, Brandl C, Wolf A, Kirchinger P, Klappers P, Schmidt M, Riethmüller G, Reinhardt C, Baeuerle PA, Kufer P. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321(5891):974-977.
Beilhack A, Schulz S, Baker J, Beilhack GF, Nishimura R, Baker EM, Landan G, Herman EI, Butcher EC, Contag CH, Negrin RS. Prevention of Acute Graft-versus-Host Disease by Blocking T-cell Entry to Secondary Lymphoid Organs. Blood. 2008;111(5):2919-2928.
2007
Meyer RG, Britten CM, Wehler D, Bender K, Hess G, Konur A, Hartwig UF, Wehler TC, Ullmann AJ, Gentilini C, Uharek L, Huber C, Kolbe K, Herr W. Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell-depleted reduced-intensity transplantation. Blood. 2007;109(1):374-382.
2005
Beilhack A, Schulz S, Baker J, Beilhack GF, Wieland CB, Herman EI, Baker EM, Cao YA, Contag CH, Negrin RS. In Vivo Analyses of Early Events in Acute Graft-versus-Host Disease Reveal Sequential Infiltration of T Cell Subsets. Blood. 2005;106(3):1113-1122.
2003
Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9(9):1144-1150.
Fritsche J, Mondal K, Ehrnsperger A, Andreesen R, Kreutz M. Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. Blood. 2003;102(9):3314-3316.
Edinger M, Hoffmann P, Contag CH, Negrin RS. Evaluation of effector cell fate and function by in vivo bioluminescence imaging. Methods. 2003 Oct;31(2):172-9.
1993
Kreutz M, Andreesen R, Krause SW, Szabo A, Ritz E, Reichel H. 1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood. 1993;82(4):1300-1307.