Every cell in our body contains the entire human genome. But because each single cell is designated a specific task, it only requires part of this genomic information to execute its function. The selection of genes that a specific cell uses is regulated by so called ‘epigenetic’ mechanisms which modify gene expression. These operate to control and memorize the identities and functions of all the different cell types in our body. Epigenetic mechanisms are essential for life, but they are often modified by diseases such as cancer. Understanding how these mechanisms work in normal cells is important to gaining a better understanding of their contribution to human diseases. To this end, the Institute seeks to develop targeted therapies—with a specific focus on the design of more efficient cellular therapies.